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   Oct 12

Smokers

Smokers present a lesser trend to develop the pathology, being proven scientifically, therefore the nicotine seems to have protective effect on the producing cells of dopamina, as well as who makes the constant use of coffee. In accordance with Bennet; Plum (1971) the corpsculos of Lewy are found eosinfilicas cytoplasmic inclusions in areas of cellular degeneration, considered as main pathological characteristic of the DP and markers of neuronal loss. The etiology of the DP can is associated with the following factors of isolated or associated form: the action of neurotoxinas-ambient, mitocondriais production of free radicals, abnormalitys, genetic predisposition cerebral aging. Fisiopatologia In accordance with Teive (2003) gradual the neuronal loss of 60% in the region ventro-lateral of the compact part of mesencfalo, seems to be responsible for the sprouting of the cardinal signals of the pathology as the posturais bradicinesia, rigidity, tremor and consequences. The neuronal loss of 60% diminishes the levels of dopamina to the level of dopamina of the situated dopaminrgicos receivers in the ganglion of the base and the estriado body. resulting in the nigro-estriatal distinction responsible mechanism for the sprouting of the rigid-acintica syndrome, that in its majority is associated with the tremor and the postural instability. As previous reference the rigid-acintica syndrome is decorente of lesser inibitria action of the lateral segment of the pale globe on the sub-talmico nucleus, and consequentemente bigger excitatria action dessse nucleus on the medial segment of the pale globe and finally lesser excitatria action of the thalamus on the motor cortex. The dopamina (inibitrio neurotransmitter) and acetilcolina (excitatrio neurotransmitter) sends messages through neurons estriados for the raised motor centers, whose purpose is to control and to stimulate the motor movements of the being the acetilcolina is in excess what it generates abnormal discharges, reaching the voluntary movements mainly and consequent comprometimento of the extrapiramidais treatments, responsible regions for the control of the complex movements of the body, unchaining tremors, rigidity and bradicinesia (SMELTZER; BARE, 2002).

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